Cost-Effectiveness of Tenecteplase Before Thrombectomy for Ischemic Stroke

L Gao; M Moodie; PJ Mitchell; L Churilov; TJ Kleinig; N Yassi; B Yan; MW Parsons; GA Donnan; SM Davis; BCV Campbell

Journal article

Cost-Effectiveness of Tenecteplase Before Thrombectomy for Ischemic Stroke

L Gao, M Moodie, PJ Mitchell, L Churilov, TJ Kleinig, N Yassi, B Yan, MW Parsons, GA Donnan, SM Davis, BCV Campbell

Stroke | Published : 2020

DOI: 10.1161/STROKEAHA.120.029666

Abstract

Background and Purpose: Tenecteplase improved functional outcomes and reduced the requirement for endovascular thrombectomy in ischemic stroke patients with large vessel occlusion in the EXTEND-IA TNK randomized trial. We assessed the cost-effectiveness of tenecteplase versus alteplase in this trial. Methods: Post hoc within-trial economic analysis included costs of index emergency department and inpatient stroke hospitalization, rehabilitation/subacute care, and rehospitalization due to stroke within 90 days. Sources for cost included key study site complemented by published literature and government websites. Quality-adjusted life-years were estimated using utility scores derived from the ..

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University of Melbourne Researchers

Peter Mitchell Author

Leonid Churilov Author

Nawaf Yassi Author

Bernard Yan Author

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Grants

Awarded by Medtronic

Funding Acknowledgements

This study was supported by Medtronic (unrestricted grant), the National Health and Medical Research Council of Australia (1043242, 1035688, 1113352, and 1111972), the Royal Australasian College of Physicians, the Royal Melbourne Hospital Foundation, the National Heart Foundation of Australia, and the Stroke Foundation of Australia, and infrastructure funding from the state government of Victoria to the Florey Institute of Neuroscience and Mental Health.